Abstract
Abstract BALB/c mice immunized with murine sarcoma virus (MSV) have been studied at various times after injection for their immunity to either extracts of MSV-induced sarcomas or preparations of disrupted whole MSV virus. The assays used were the inhibition of normal macrophage migration, in the presence of immunizing antigen and sensitized cells, or the stimulation of protein or DNA synthesis in immune cells themselves, caused by the addition of the immunizing antigen. Each assay system is shown to detect specific anti-MSV-induced immunity in both the spleen and lymph node of infected mice. The immune cells causing the effects observed in the systems tested seem to be T lymphocytes, as judged by the effect of anti-θ antiserum. Evidence is presented that two physically distinct populations of cells exist which can respond to MSV and show a net increase in total DNA or protein synthesis. However, only one of these cells seems able to release factors able to cause macrophage migration inhibition.
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