Abstract
Immunity to Plasmodium falciparum develops slowly in regions of endemicity, such that infection is more frequent and severe in children than in adults. A long unbroken period of heavy exposure is needed to acquire protective immunity sufficient to limit parasitaemia and disease, but this resistance is neither sterile nor permanent. The means by which acquired immunity develops is a matter for contention. The argument for cumulative exposure is based on the widely held notion that the parasite is poorly immunogenic and/or that immunity is strain specific and requires exposure to the many parasite variants transmitted within a malarious community 1xNaturally acquired immunity to Plasmodium falciparum. Day, K.P. and Marsh, K. Parasitol. Today. 1991; 7: A68–A71Abstract | Full Text PDF | Scopus (19)See all
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