Abstract
Abstract Mice were immunized by intraperitoneal or intravenous infection with sublethal inocula of one of four strains of Staphylococcus aureus. Intraperitoneal (IP) or intravenous (IV) challenge with ordinarily lethal inocula was performed 2 weeks later. IV immunization protected against subsequent IP or IV challenge with homologous or heterologous strains. IP immunization protected against IP but not against IV challenge. Increased resistance to staphylococcal infection was associated with enhanced phagocytosis by peritoneal macrophages and by polymorphonuclear leukocytes. Following IV challange, immunized animals also demonstrated an increased ability to mobilize leukocytes into the peritoneal cavity. Mice protected against challenge with living staphylococci also survived longer than controls after infection with Klebsiella pneumoniae but were not protected against inoculation of lethal amounts of staphylococcal toxin.
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