Abstract
AbstractMonoclonal immunoglobulins (heavy and/or light chain) can deposit in various organs. The most prominent targeted organs are the kidney, the nerves, the heart, the liver, the gastrointestinal tract but it could also involve the eyes, the skin and it can interact with the hemostasis proteins. This is at the origin of a new concept called monoclonal gammopathy of clinical significance (MGCS). It is challenging to diagnose and even though the B cell clone may be small, it may be important, in some circumstances, to initiate a hematological treatment.
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