Immune Thrombocytopenia as a Presenting Manifestation of Hodgkin’s Lymphoma

Abstract

Autoimmune hematological disorders may be the initial indicator of an underlying Hodgkin lymphoma (HL). Immune thrombocytopenia (ITP) can manifest before, during, or after the diagnosis of HL, and concurrent thrombocytopenia can complicate the diagnosis and initial treatment of the malignancy. Various autoimmune disorders have been described in patients with HL, including ITP, autoimmune hemolytic anemia, autoimmune neutropenia, systemic lupus erythematosus, and scleroderma. An underlying HL should be considered in the differential diagnosis of a pediatric patient with ITP. In this report, we present the case of a 5-year-old boy who had thrombocytopenia and fever at the time of his HL diagnosis. Based on bone marrow aspiration and evaluation, we diagnosed immune thrombocytopenia and administered treatment with intravenous gammaglobulin. The platelet count normalized within a few days of treatment