Abstract
The major components of host defense include anatomical barriers, and the innate and adaptive immune systems. Integrity of the anatomical and mucociliary barrier (i.e., skin and mucous membranes) is essential for protection against infection, and defects in this barrier function can lead to infections. The innate immune system acts as the first line of defense against pathogens, responding rapidly but nonspecifically before the development of the more versatile adaptive immune system
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