Abstract
We have read with great interest the recent article by Crepin et al.1 on the clinical impact of an immune risk phenotype (IRP) on the susceptibility to post-transplant infection in a cohort of 486 patients with end-stage renal disease (ESRD) undergoing kidney transplantation (KT). By using some broadly available parameters (namely peripheral blood lymphocyte subpopulations [PBLSs] and cytomegalovirus [CMV] serostatus), the so-called IRP aims to summarize the spectrum of functional changes involved in the CMV-driven process of premature immune senescence.2,3 The authors found that IRP at the time of transplantation was predictive of opportunistic infection (OI) and serious bacterial infection, as well as to be associated with a numerically lower rate of acute graft rejection (AR).1 If these findings are validated, the assessment of baseline IRP might be added to the current repertoire of immune monitoring strategies as an useful surrogate to individualize prevention approaches against post-transplant infection.4 This article is protected by copyright. All rights reserved.
Published Version
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