Abstract
Anti-idiotypic antisera against the PC-binding Balb/c myeloma protein H8 were induced in A/He and Balb/c mice and a rabbit anti-H8 antiserum was rendered specific for the H8 idiotype by absorption. These different anti-idiotypic antisera were compared using inhibition of anti-PC plaque formation by immune Balb/c spleen cells. The inhibition profiles of the murine anti-idiotypic antisera resemble the inhibition curve obtained by free hapten PC while the heterologous anti-idiotypic antiserum has a profile similar to one obtained with a heterologous anti-μ serum. This finding indicates restriction in specificity and antibody heterogeneity of homologous and isologous and isologous anti-idiotypic antibodies raised against the H8 idiotype.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
