Abstract
This study evaluated the immunogenicity and immune duration of the locally produced inactivated foot and mouth disease (FMD) vaccine, currently used in Egypt as the main control of the disease. Three batches of FMD vaccines inactivated with binary ethyleneimine were prepared: two double oil emulsion (DOE) lots with either Arlacel A or Spane 80 as emulsifier and a 30% alhydragel vaccine. Evaluation and testing of FMD vaccine containing different adjuvants for safety, sterility, and potency were carried out. Guinea pig protective dose 50 (GPPD 50) was determined for each batch separately. The evaluation of three different types of vaccines in sheep revealed that the DOE–FMD vaccine using the new emulsifier Spane 80 showed much higher antibody titers and longer duration of immunity than the other two vaccine preparations.
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