Abstract
The immunomodulatory effects of aflatoxin B1 (AFB1) on mice experimentally infected with Encephalitozoon cuniculi (E. cuniculi) were studied. Mice inoculated intraperitoneally with spores of E. cuniculi drank a daily solution of AFB1 (0.2 mg kg−1 of body weight) for 27 days. Application of AFB1 to mice demonstrated a decrease of immunocompetent cells. On the other hand, the mice infected with E. cuniculi and given AFB1 showed significant increased number of both monocytes and CD8+ T cells, and tendency to a decrease in CD4+ T cells. Aflatoxin B1 revealed to merely modulate systemic immune response of E. cuniculi infected mice.
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