Abstract
Experiments were conducted in rats on the immunogenicity of 500 T. spiralis larvae subjected to roentgen irradiation at doses varying from 0 to 20,000 r before injection tn the rats. One month later the rats were challenged with 5000 nonirradiated larvae, and 2 months later the number of larvae in muscle were determined. The number recovered was found to increase linearly with the radiation dose, between 8000 and 20,000 r, applied to the larvae used for immunization. This indicates a progressive decline in immunogenicity with increasing radiation dosage in this range. However, larvae exposed to 8000 or 12,000 r were more potent immunologically than nonirradiated larvae. In rats which received only an immunizing inoculation of larvae, fewer larvae were found in muscle with irradiated than nonirradiated larvae, indicating that radiation limited the reproductive capacity of the worms. (H.H.D.)
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