Abstract
Background: Preoperative chemotherapy followed by curative-intent resection represents the mainstay in treatment of advanced colorectal cancer liver metastases (CRCLM). The host immune response classified by the presence of tumour-infiltrating lymphocytes (TILS) has been verified as a major contributor to oncological outcome in several malignant diseases including colorectal cancer. This study characterizes the immune cell distribution in different tumour compartments by flow cytometry and immunohistochemistry to establish a link between immune response and pathological tumour regression grading (TRG) in patients undergoing liver resection for CRCLM.
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