Immune Response After Three Doses of Hepatitis B Vaccine among Children Below Five Years of Age in Mwanza, Tanzania

Delfina R Msanga,Stephen E Mshana,Tulla Masoza,Elizabeth Kwiyolecha,Emmanuel Mkumbo,Raphael Rwezaula,Semvua Kilonzo,Mariam M Mirambo

doi:10.34257/gjmrcvol20is5pg25

Abstract

Background: Hepatitis B virus (HBV) infections is moderately endemic in many countries in the sub-Saharan Africa including Tanzania. Immunization of children below five years of age has been found to be an effective strategy in controlling infectious diseases. However, the data regarding immune responses following vaccination are very limited in low-income countries. Here, we report the sero-conversion among children below five years of age after three doses of HBV vaccine in Mwanza, Tanzania. Methodology: A cross-sectional study involving children below five years of age was conducted at Makongoro Reproductive and Child Health (RCH) clinic between May and June 2017. Socio-demographic data were collected, and vaccination status was confirmed from reproductive and child health (RCH) cards. Serum HBV surface antibodies (anti-HBs) were quantified using enzyme immunoassay (Enzygnost Anti-HBs II). Data were analysed by using STATA version 13 software.

Highlights

Catholic University of Health and Allied Sciences Abstract- Background: Hepatitis B virus (HBV) infections is moderately endemic in many countries in the sub-Saharan Africa including Tanzania
We report the sero-conversion among children below five years of age after three doses of HBV vaccine in Mwanza, Tanzania
A total of 300 children were enrolled with the median measure to prevent HBV infections

Summary

Introduction

Catholic University of Health and Allied Sciences Abstract- Background: Hepatitis B virus (HBV) infections is moderately endemic in many countries in the sub-Saharan Africa including Tanzania. The data regarding immune responses following vaccination are very limited in low-income countries. Background: Hepatitis B virus (HBV) infections is Keywords: hepatitis B, children, immune response, moderately endemic in many countries in the sub-Saharan seroconversion, mwanza, Tanzania. I. Backgrounds immune responses following vaccination are very limited in low-income countries. We report the sero-conversion among children below five years of age after three doses of HBV vaccine in Mwanza, Tanzania

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Results

Discussion

Conclusion