Immune reconstitution inflammatory syndrome in a patient with adult-onset Still's disease: Graft-versus-host-like skin reaction with possible asymptomatic human herpes virus reactivation during steroid tapering

Abstract

Immune reconstitution inflammatory syndrome (IRIS) was originally reported in a human immunodeficiency virus (HIV) patient. It is an excessive inflammatory reaction to an opportunistic infection that occurs in HIV patients with profound immunosuppression during the reconstitution of the immune system in the initial months of highly active antiretroviral therapy (HAART). Within 1-2 weeks after the initiation of HAART therapy, the serum HIV RNA level is reduced and CD4+ T cell counts are increased, [...]