Abstract
Regional pelvic lymph node lymphocytes from 23 patients with prostatic carcinoma were tested in vitro for their ability to proliferate in response to T- and B-cell mitogens. Regional lymph node lymphocytes were significantly more reactive when obtained from nodes morphologically displaying either a normal histologic pattern or T and B lymphocyte hyperplasia than from those that histologically appeared lymphocyte depleted. In vitro lymphocyte responses from normal appearing nodes in the cancer patients were similar to those observed by lymph node lymphocytes obtained from pelvic lymph nodes in patients with nonmalignant diseases. The data suggest that regional lymph node lymphocytes in prostatic cancer patients are functionally capable of participating in an active anti-tumor immune response. Furthermore, lymphocyte, depletion appeared to have a negative prognostic impact independent of stage and grade of disease. Morphology of regional lymph nodes in prostatic cancer may reflect immunologic defense mechanisms in host and therefore be of individual prognostic significance.
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