Abstract
Evaluation of: Hatton JL, Parent A, Tober KL et al. Depletion of CD4+ cells exacerbates the cutaneous response to acute and chronic UVB exposure. J. Invest. Dermatol. 127, 1507–1515 (2007).And: Loser K, Apelt J, Voskort M et al. IL-10 controls ultraviolet-induced carcinogenesis in mice. J. Immunol. 179, 365–371 (2007).Skin cancer represents the commonest form of human cancer in fair-skinned people, with the most important risk factors being life-time exposure to sunlight and episodes of severe sunburning. The two papers discussed here examine critical immunological parameters that protect against skin cancer development in mice chronically exposed to UV radiation. CD4+ T cells were shown to limit the cutaneous inflammatory response to acute UV exposure, and these cells protected against photocarcinogenesis by regulating inflammation in the skin. IL-10, presumably produced by CD4+CD25+ T regulatory cells, was revealed to be a crucial immunosuppressive agent in photocarcinogenesis. Based on these results, s...
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
