IMMUNE-MICROENVIRONMENT DYNAMICS IN CANCER: IMPLICATIONS FOR IMMUNOTHERAPY

Perini Turupati,Department Of Biomedical Engineering, University Of North Texas, 3940 N Elm St, Denton, Texas, Usa ,Department Of Biomedical Engineering, University Of North Texas, 3940 N Elm St, Denton, Texas, Usa ,Manikanta Amanchi,Jasvitha Boyapati,Abhinaya Sravani Kuchibhotla,Santhi Priya Amarthaluri,Saikiran Udarapu,Department Of Biotechnology, Koneru Lakshmaiah Education Foundation, Vaddeswaram, Guntur, Andhra Pradesh, India ,Ishika Manohar Irkullawar,Department Of Biotechnology, Koneru Lakshmaiah Education Foundation, Vaddeswaram, Guntur, Andhra Pradesh, India ,Department Of Biomedical Engineering, University Of North Texas, 3940 N Elm St, Denton, Texas, Usa ,Pavani Durga Posa,Department Of Biomedical Engineering, University Of North Texas, 3940 N Elm St, Denton, Texas, Usa ,Department Of Biomedical Engineering, University Of North Texas, 3940 N Elm St, Denton, Texas, Usa ,Department Of Biotechnology, Sri Venkateshwara College Of Pharmacy, Madhapur, Hyderabad, Telangana, India

doi:10.21474/ijar01/18800

Perini Turupati, Department Of Biomedical Engineering, University Of North Texas, 3940 N Elm St, Denton, Texas, Usa + Show 14 more

Open Access

https://doi.org/10.21474/ijar01/18800

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Abstract

Understanding the intricate interplay between cancer cells and the immune microenvironment is crucial for advancing immunotherapy strategies. This review explores the intricate landscape of the TME, focusing on its diverse cellular and molecular components and their roles in immune evasion and immunotherapy response. The tumor microenvironment (TME) comprises a complex network of immune cells, stromal cells, and soluble factors that dynamically interact with cancer cells. This dynamic crosstalk shapes the tumors immune landscape, influencing tumor progression, metastasis, and response to therapy. In recent years, immunotherapy has revolutionized cancer treatment by targeting immune checkpoints, enhancing immune cell activation, and modulating the TME. However, the heterogeneous nature of the TME and the evolving tumor-immune interactions pose challenges for effective immunotherapy. This review discusses the diverse cellular and molecular components of the TME, their roles in immune evasion, and the mechanisms underlying response or resistance to immunotherapy. Insights gained from unraveling the complexities of the TME hold promise for developing personalized immunotherapy approaches tailored to individual patients.

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