Immune Microenvironment Change and Involvement of Circular RNAs in TIL Cells of Recurrent Nasopharyngeal Carcinoma.

Yumin Wang,Weihong Jiang,Ruohao Fan,Hua Zhang,Yaxuan Wang,Yi Yang,Kelei Gao,Zhouying Peng,Zhihai Xie

doi:10.3389/fcell.2021.722224

Abstract

Nasopharyngeal carcinoma is a malignant tumor that is highly prevalent in southern China and the Southeast Asian belt. Recent studies have shown that the T cells play important regulatory roles in tumorigenesis and progression. We test TIL cell of recurrent nasopharyngeal carcinoma and primary nasopharyngeal carcinoma cell. We found that T cell change in recurrent nasopharyngeal carcinoma and primary nasopharyngeal carcinoma cell. Based on GEO database, we selected differently expressed circRNAs in nasopharyngeal carcinoma tissues. qRTPCR show that some circRNAs also highly expressed in TIL cells. In conclusion, immune microenvironment changed in recurrent nasopharyngeal carcinoma. There is involvement of circular RNAs in this progress, with should be researched further.

Highlights

Nasopharyngeal carcinoma is a malignant tumor that is highly prevalent in southern China and Southeast Asian (Hanahan and Weinberg, 2011; Chen et al, 2019; Jiang et al, 2020)
Nasopharyngeal carcinoma is a malignant tumor of nasopharyngeal epithelial origin, and the treatment of primary nasopharyngeal carcinoma is mainly based on radiation therapy (Wang et al, 2019; Peng et al, 2021)
Most nasopharyngeal carcinomas are initially sensitive to radiation therapy, more and more clinical applications have found that most nasopharyngeal carcinomas will develop radiation therapy resistance and recurrence

Summary

Introduction

Nasopharyngeal carcinoma is a malignant tumor that is highly prevalent in southern China and Southeast Asian (Hanahan and Weinberg, 2011; Chen et al, 2019; Jiang et al, 2020). The preferred treatment for nasopharyngeal carcinoma is radiation therapy. Clinical studies have found that recurrence has become the main cause of treatment failure in nasopharyngeal carcinoma (Liu et al, 2021; Wu et al, 2021). Recent studies have shown that the process of nasopharyngeal carcinogenesis and progression is influenced by the immune microenvironment. In which T cells, as the main component of specific immunity, especially cellular immunity, play an important role in the development of tumor (Xia et al, 2021). Among the T cells, Treg, CD4 + T, CD8 + T, and other major T cell taxa play important regulatory roles in tumorigenesis and progression

Methods

Results

Conclusion