Abstract
BackgroundThe rate of progression of the disease depends on various factors and the tumor microenvironment takes not the last place among them. One part of researchers argues that the presence of tumor-infiltrating leukocytes serves as a favorable marker of the disease. There exists a completely different point of view on the matter.The investigation of the effects of the inflammatory infiltration on the course of breast cancer process.MethodsWe found a pronounced inflammatory infiltration in the tumor microenvironment in 24 cases. Nineteen cases of IDC without inflammatory infiltration were used as a control group. Immunohistochemical reaction showed expression of ERα, PR, HER2/neu, E-cadherin, Hsp90α, Bcl-2, CD3, CD79α, S100 and Myeloperoxidase receptors. Mathematical calculations were done using Microsoft Excel 2010 with 12.0.5 Attestat option.ResultsWe have determined five variants of immune microenvironment: interstitial, trabecular, nodular, diffuse and mixed. We have established a direct correlation between the expression of ERα and PR and indirect correlation between the receptors of steroid hormones and HER2/neo in both groups of breast cancer. HER2/neo positive tumors in 100% of cases were accompanied by the presence of heat shock proteins. There was a combination of Bcl-2 presence with the steroid receptors expression in 90 % of cases. There was found the indirect correlation between the presence of B lymphocytes and expression of steroid receptors.ConclusionsThe presence of B lymphocytes in an inflammatory infiltrate leads to the disappearance of estrogen receptors and progesterone receptors. It provokes the accumulation of Hsp90 in a cell. It contributes to the stabilization of HER2/neu receptors and most proteins that promote tumor progression.Virtual slidesThe virtual slides for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/vs/1362330168161694
Highlights
The rate of progression of the disease depends on various factors and the tumor microenvironment takes not the last place among them
We found that most cells had a rounded shape with a rounded nucleus and a small amount of cytoplasm of approximately 6mkm which were identified as lymphocytes
We have established a direct correlation between the expression of ERα and PR (r = +0.78, p < 0.05) and indirect correlation between the receptors of steroid hormones and HER2/neo (r = −0.73, p < 0.05) in both groups of breast cancer
Summary
The rate of progression of the disease depends on various factors and the tumor microenvironment takes not the last place among them. The self-regulation tumorous process and participation of antitumor immunity in it are acute in many scientific studies From this perspective the tumor microenvironment occupies a key position. It has been shown that the immune microenvironment determines the proliferative activity of the tumor, metastasis and cell migration This process is carried out by the ability of cells to perceive signaling molecules such as pro-inflammatory cytokines, selectins, chemokines which are secreted by inflammatory cells as well as secrete them. As it turned out the prognosis of breast cancer depends more on qualitative composition of the infiltration [10]
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