Abstract
A 10-year-old, female, mixed breed dog was admitted to the animal hospital with signs of jaundice, pigmenturia, depression, and splenomegaly. Hematology revealed non-regenerative anemia, thrombocytopenia, leukopenia with numerous spherocytes, and a few undifferentiated blasts on a blood smear. A bone marrow examination indicated high M:E ratio with increased number of leukemic cells. Based on cytochemistry and protein electrophoresis, the patient was diagnosed with immune-mediated hemolytic anemia with acute monoblastic leukemia.
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