Abstract
Sepsis is a host immune disorder induced by infection. It can lead to multiple organ dysfunction syndrome (MODS), which has high morbidity and mortality. There has been great progress in the clinical diagnosis and treatment of sepsis, such as improvements in pathogen detection technology, innovations regarding anti-infection drugs, and the development of organ function support. Abnormal immune responses triggered by pathogens, ranging from excessive inflammation to immunosuppression, are recognized to be an important cause of the high mortality rate. However, no drugs have been approved specifically for treating sepsis. Here, we review the recent research progress on immune responses in sepsis to provide a theoretical basis for the treatment of sepsis. Constructing and optimizing a dynamic immune system treatment regimen based on anti-infection treatment, fluid replacement, organ function support, and timely use of immunomodulatory interventions may improve the prognosis of sepsis patients.
Highlights
Immune Intervention in SepsisReviewed by: Jonathan Boomer, University of Kansas Medical Center, United States Peter A
Sepsis is a life-threatening syndrome caused by an abnormal infection-induced immune response
In the remaining circulatory dendritic cells (DCs) in sepsis patients, Human leukocyte antigen-DR (HLA-DR), CD80, and CD86 are downregulated, while IL-10 production is increased (Faivre et al, 2012), which is consistent with their reduced ability to induce effector T cell responses and their ability to prevent the response of T cells and the proliferation of Treg cells (Faivre et al, 2007; Wen et al, 2008)
Summary
Reviewed by: Jonathan Boomer, University of Kansas Medical Center, United States Peter A. Sepsis is a host immune disorder induced by infection. There has been great progress in the clinical diagnosis and treatment of sepsis, such as improvements in pathogen detection technology, innovations regarding anti-infection drugs, and the development of organ function support. Abnormal immune responses triggered by pathogens, ranging from excessive inflammation to immunosuppression, are recognized to be an important cause of the high mortality rate. We review the recent research progress on immune responses in sepsis to provide a theoretical basis for the treatment of sepsis. Constructing and optimizing a dynamic immune system treatment regimen based on anti-infection treatment, fluid replacement, organ function support, and timely use of immunomodulatory interventions may improve the prognosis of sepsis patients
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
