Abstract
With the introduction of intravenous formulations, the use of immune globulins, once limited to IgG replacement in severe humoral immunodeficiencies, has been extended to include the prevention or treatment of a wide variety of infections and immunologic disorders.1 , 2 Though the role of immune globulin in the prevention of systemic and sinopulmonary bacterial infections in agammaglobulinemia is well established, its role in the management of more subtle humoral immunodeficiencies associated with B-cell neoplasms, bone marrow transplantation, and IgG-subclass deficiencies remains controversial.1 , 2 In premature babies, a physiologic hypogammaglobulinemia due to reduced transplacental transfer and endogenous synthesis of IgG provides a strong rationale . . .
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