Abstract
Lactic acid bacteria (LAB) are known to promote the activation of the macrophage, selectively eliminate the harmful intestinal bacteria that enter the body, and increase secretion of cytokines, chemokines, and inflammatory mediators which boost the immune system. In the present study, the immune-enhancing effects of five Leuconostoc stains (Leu. kimchii WK18, Leu. citreum DH33, Leu. mesenteroides DH34, SE34, and GY17) isolated from Korean traditional fermented food, Kimchi, were evaluated. Lactobacillus rhamnosus GG, (LGG) which is known for its extraordinary immunopotentiating activity was used as a reference strain. The results showed that several heatkilled Leuconostoc strains induced higher level of NO, IL-1β, or TNF-α production than LGG strain. Collectively, the present study suggests that Leuconostoc strains could enhance immune response by activating macrophages, and could be significant references when verifying the possibility for Leuconostoc strains to be a probiotics, starter, dietary supplement, or immune-enhancing medicine.
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