Abstract
Stem Cells Hair follicles in mammalian skin undergo cycles of quiescence and regeneration. Hair follicle stem cells play a role in the regeneration phase. Ali et al. have found that regulatory T cells (Tregs), immune cells known to suppress inflammation, colocalize with stem cells in hair follicles. In a mouse model of hair regeneration, depletion of Tregs reduced hair growth. Analysis of gene expression revealed that Tregs promote the proliferation and differentiation of hair follicle stem cells. Tregs express a high level of Jagged, a ligand of the cell-cell communication system called the Notch signaling pathway that controls stem cell self-renewal and differentiation. The findings may have implications for treating individuals with alopecia areata, a hair loss condition. Cell 10.1016/j.cell.2017.05.002 (2017).
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