Abstract
This review addresses the immune consequences of Chlamydial infections in pregnancy and in vitro fertilization (IVF) outcome. In pregnancy, many works have shown the risk for perterm labor, preterm birth, or miscarriage with current infection, and stress the need for screening and treatment early in pregnancy. IVF outcome needs to be studied in relation to specific markers like inflammatory cytokines and secretory antibodies to the 60 kD heat shock protein (hsp60) and to Chlamydia, to determine their ability to predict and influence pregnancy outcome. © 1996 Wiley-Liss, Inc.
Highlights
This review addresses the immune consequences of Chlamydial infections in pregnancy and in vitro fertilization (IVF) outcome
In pregnancy and IVF outcome, sequelae differ according to the specific immune responses that are induced
It has been demonstrated that chlamydial antibodies and chlamydial hsp are related to induction of inflammatory cytokines,37’45 hsp strongly induces T-cell and macrophage activation and cytokine production, and that the immune response is restricted by certain regions of the MHC.[46]
Summary
This review addresses the immune consequences of Chlamydial infections in pregnancy and in vitro fertilization (IVF) outcome. Another recent work finds a positive correlation between hsp[60] antibodies to the chlamydial 60kD heat shock protein (chsp 60)
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