Abstract
Circulating immune complexes (IC) are often detected in patients with primary biliary cirrhosis (PBC). To investigate the nature of the antigen(s) present in IC, sera of 15 patients were incubated with an excess of the suspected antigens. The addition of mitochondrial antigens resulted in dissociation of IC in sera of 6 of 15 patients with PBC but not of 5 patients with alcoholic hepatitis nor 5 patients with rheumatoid arthritis. These data indicate that in some patients with PBC, circulating IC contain mitochondrial antigens.
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