Abstract
Background The long-term goal for an efficacious HIV vaccine is to provide sterilizing protection from HIV infection. Thus far, this scenario has only been achieved experimentally using live-attenuated SIV vaccines. As such, great interest lies in identifying correlates of protection from a successful host response to pathogenic SIV. To this end, we have used a global genomics approach, tissue analysis, and explant cultures to identify immune complex (IC) signaling as an important component of a protective host response in the female reproductive tract (FRT) of animals vaccinated with the live-attenuated virus known as SIV mac239 ΔNef.
Highlights
The long-term goal for an efficacious HIV vaccine is to provide sterilizing protection from HIV infection
Immune complexes can dampen inflammatory signaling at the mucosal surface during protective SIV vaccination
Great interest lies in identifying correlates of protection from a successful host response to pathogenic SIV
Summary
The long-term goal for an efficacious HIV vaccine is to provide sterilizing protection from HIV infection. Far, this scenario has only been achieved experimentally using live-attenuated SIV vaccines. Great interest lies in identifying correlates of protection from a successful host response to pathogenic SIV. To this end, we have used a global genomics approach, tissue analysis, and explant cultures to identify immune complex (IC) signaling as an important component of a protective host response in the female reproductive tract (FRT) of animals vaccinated with the live-attenuated virus known as SIV mac239 ΔNef
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