Immune complex-induced inhibition of osteoclastogenesis is mediated via activating but not inhibitory Fcγ receptors on myeloid precursor cells

Abstract

ObjectiveTo investigate the role of Fcγ receptors (FcγRs) in osteoclastogenesis and osteoclast function.MethodsBone destruction was analysed in arthritic knee joints of several FcγR-knockout mouse strains. Unfractionated bone marrow cells were...