Abstract
Acute myeloid leukemia (AML) is one of the most common types of hematopoietic malignancy in the adults. Induction chemotherapy followed by post-remission is the general treatment for AML patients with high relapse rate and poor prognosis, which is often related to the CD8+ T cell immune status of the AML patients. Herein, we will make a mini review of phenotype-immune checkpoints expression and function of CD8+ T cells in AML based on our data and other groups, and this might indicate the application of immune checkpoints blockade alone or in combination in AML treatment.
Highlights
Acute myeloid leukemia (AML) is one of the most common types of hematopoietic malignancy in the adults
Induction chemotherapy followed by post-remission is the general treatment for AML patients with high relapse rate and poor prognosis, which is often related to the CD8+ T cell immune status of the AML patients [1-4]
We will make a mini review of phenotype-immune checkpoints expression and function of CD8+ T cells in AML based on our data and other groups, and this might indicate the application of immune checkpoints blockade alone or in combination in AML treatment
Summary
Acute myeloid leukemia (AML) is one of the most common types of hematopoietic malignancy in the adults. About AML, impressive results have been obtained with PD-1 alone or in combination with other immune checkpoint blockade in mouse AML models, by improving anti-leukemia CD8+ T cell function. This suggests that blockade of the immune checkpoint has the role of anti-leukemic effect in AML [10,11]. Blockade of TIGIT and PD-L1 synergistically enhanced CD8+ T cell function and resulted in tumor rejection [19]. These data show that AML patients had increased immune checkpoints expression, whereas blocking these checkpoints can exert anti-leukemic effects
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
