Abstract
Myocarditis is a life-threatening complication of immune checkpoint inhibitor therapy. Over the past ten years, drugs in this group have been used in the treatment of a wide range of hematological diseases and solid tumors. With steadily growing life expectancy of cancer patients, problems associated with treatment complications are increasingly coming to the fore. Since 2016, publications have appeared on cases of autoimmune myocarditis during checkpoint inhibitor therapy (CIT), among which there are quite a few single-center retrospective and observational studies. At the same time, the problem of diagnosis and treatment of immune checkpoint inhibitor myocarditis remains unresolved.This paper presents a review on the problem of immune checkpoint inhibitor myocarditis, as well as the results of a systematic analysis of PubMed database publications.
Highlights
Миокардиты относятся к жизнеугрожающим осложнениям противоопухолевой терапии моноклональными антителами, ингибирующими контрольные точки им мунитета
Since 2016, publications have appeared on cases of autoimmune myocarditis during checkpoint inhibitor therapy (CIT), among which there are quite a few single-center retrospective and observational studies
This paper presents a review on the problem of immune checkpoint inhibitor myocarditis, as well as the results of a systematic analysis of PubMed database publications
Summary
Миокардиты относятся к жизнеугрожающим осложнениям противоопухолевой терапии моноклональными антителами, ингибирующими контрольные точки им мунитета. Ные антитела, ингибирующие контрольные точки иммунного ответа (Checkpoint-ингибиторы или ингибиторы контрольных точек — ИКТ), способны восстанавливать противоопухолевый иммунный ответ, провоцируя тем самым гибель опухолевых клеток посредством действия на уровне различных сигнальных молекул, таких как цитотоксический Т-лимфоцитарный антиген 4 (CTLA-4), белок, про- С каждым годом на фоне иммунной противоопухо левой терапии растет и число документированных случаев развития сердечно-сосудистых осложнений (ССО), которые становятся серьезной проблемой и ассоциированы с высоким процентом летальности [3,4,5].
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