Abstract
Gestational stress has been extensively studied in order to clarify its effects on behavioral and neurodevelopmental in both mother and offspring. Our study was deflected to investigate the pregestational psychological stress, the relationship between parameters of the immune system and the neurobehavioral changes (spatial memory). The stress was applied in female albino wistar rats, were submitted to chronic restraint stress for 1h/day for 4 days a week during 5 weeks before gestation. The behavior of rats and offspring was assessed in the Morris water maze test and the immune system by measuring the plasma concentration of IgG, which are the only immunoglobulin able to cross the placenta. Our results showed a change in the concentration of IgG, immune system cells and disturbance of spatial memory (Morris water maze). Key words: pregestational stress, immune parameters, spatial memory
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