Abstract
Bioprosthetic heart valves are prone to structural valve deterioration (SVD) due to an inflammatory immune response resulting in calcification, stenosis, and ultimately valve failure. The antigenicity of xenografts is thought to underlie the immune response, with galactose-α-1,3-galactose (alpha-gal) the principal antigen of investigation. The objective of this study is to further characterize the role of alpha-gal in SVD and determine whether the addition of alpha-gal cleavage to tissue engineered porcine aortic valve (PAV) leaflets will attenuate the xenoreactive humoral immune response.
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