Abstract
Immune Alterations in Liver Cirrhosis: Its Relationship with Etiology,Child Pugh Stage and Malnutrition
Highlights
The immune alterations in patients with liver cirrhosis vary, they are not universal and only a few have been able to be correlated with the severity of the disease or its prognosis
A descriptive transversal study was carried out at the Institute of Gastroenterology in Havana, Cuba from March 2008 to May 2010 in 76 patients with a confirmed diagnosis of liver cirrhosis, divided into three groups according to the etiology, 55 viral (34 by hepatitis C virus, 17 by hepatitis B virus and 4 co-infected by both viruses), 11 alcoholics and 10 of a predominantly metabolic cause
The Child Pugh stage with A: 52, B:17 and C: 7. the viral cause predominated in both sexes, alcoholism was more in males
Summary
The immune alterations in patients with liver cirrhosis vary, they are not universal and only a few have been able to be correlated with the severity of the disease or its prognosis. Cirrhotic patients have an increased intestinal permeability which enables the passage of endotoxins generated by gram negative bacteria from the intestine to the lymphatic and blood stream. The latter stimulates the liberation of mediators of the inflammatory response and nitric oxide, these being responsible in a great manner for the catabolic state and the hiperdynamic circulation of the disease [14]. Immune alterations in liver cirrhosis are variable and only a few have been correlated with the severity of the disease, malnutrition or its etiology
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