Abstract
Immobilized Artificial Membranes (IAMs) are monolayers of phospholipid analogs covalently bonded to the surface of silica particles. 31P NMR and molecular dynamics (MD) simulations demonstrated that IAMs and liposome membranes exhibit similar interfacial properties. These similar interfacial properties have resulted in IAMs' being useful as a physico-chemical model of drug-membrane partitioning. IAM chromatography has been successful used to predict: (1) solute partitioning into liposome membranes; (2) drug permeability through Caco-2 cells; (3) drug intestinal absorption; (4) brain uptake of amino acids; (5) bile salt-membrane interactions; and (6) human skin permeability of steroids and alcohols. In addition, IAM chromatography has also been used to obtain hydrophobicity parameters for SAR studies.
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