Abstract
An important effectiveness factor of probiotic therapy is the survival of cells in the gastrointestinal tract and their integration into the intestinal biofilm. The possibility of creating complex preparations of enterosorbent-probiotic on the basis of dry highly dispersed silica and methyl-silicic acid hydrogel has been investigated. The survival of Streptococcus thermophilus and Bifidobacterium longum monocultures in the composition of lyophilized complex preparations, in particular under the simulated conditions of the gastrointestinal tract, was studied. The rheological and biotechnological parameters of yoghurt fermented with S. thermophilus IMV B-7249 strain immobilized in a hydrogel were evaluated. It was determined that the functional state of the culture immobilized in highly dispersed silica remained corresponded to the proper technological parameters of sour-milk yoghurt, and the effective viscosity and stability of the product increased. This makes it possible to recommend such a preparation for a use not only for enteral use but also for the production of fermented milk products.
Highlights
One of the areas for the treatment of dysbiosis is the use of probiotic cultures of microorganisms used as fermentation cultures in fermented milk drinks, or lyophilized forms of drugs for oral taking
The aim of our research was to study the possibility of sorption of probiotic cultures on samples of dry highly dispersed silica and methyl silicic acid hydrogels and to assess their functional status by technological parameters of yoghurt fermented on the basis of strain S. thermophilus IMB B-7249
As can be seen from the photo, the cells of microorganisms with a powder sorbent (Sillard P) are grouped around the sorbent particles aggregates, which indicates the immobilization of probiotic cultures on a highly dispersed silicon preparation
Summary
One of the areas for the treatment of dysbiosis is the use of probiotic cultures of microorganisms used as fermentation cultures in fermented milk drinks, or lyophilized forms of drugs for oral taking. Older cells have less negatively charged sialic acid residues on the surface, and are subject to hemolysis much more often than young erythrocytes (Dalal, et al, 1990). It follows that for better preservation, the culture must be young. The data obtained after treatment of cells with substances that destroy the membrane indicate the importance of membrane proteins in the mechanism of binding to nano-silica This is evidenced by a decrease in the membrane-tropic activity of the sorbent after modification of the membranes by adding trypsin, lysozyme and EDTA to the cell suspension. The aim of our research was to study the possibility of sorption of probiotic cultures on samples of dry highly dispersed silica and methyl silicic acid hydrogels and to assess their functional status by technological parameters of yoghurt fermented on the basis of strain S. thermophilus IMB B-7249
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