Immobilization of povidone-iodine on surfaces of silica gel particles and bactericidal property

Abstract

A novel antibacterial material I 2-PVP/SiO 2, on which povidone-iodine (PVP-I 2) was loaded, was synthesized by a two-step route. Polyvinylpyrrolidone (PVP) was firstly graft-polymerized onto the surfaces of micro-sized silica gel particles, obtaining the grafted particles PVP/SiO 2. Subsequently, the grafted particles PVP/SiO 2 were allowed to undergo a complexation reaction with iodine, resulting in a water-insoluble antibacterial material, I 2-PVP/SiO 2. The effects of various factors on the complexation reaction were examined. The antibacterial property of I 2-PVP/SiO 2 was investigated by using Escherichia coli ( E. coli) as model bacterium and with the colony count method. The experimental results show that the fitting temperature for the complexation reaction between PVP/SiO 2 and I 2 is 60 °C, and the complexation reaction reaches equilibrium after 12 h. The particles I 2-PVP/SiO 2 have very strong antibacterial activity and they have the sterilizing mechanism similar to povidone-iodine.