Immobilization of Particulate Systems on the Skin by the Mean of Emulsions

Abstract

AbstractFor controlled delivery purposes, it can be interesting to immobilize polymeric particles onto the surface of the skin for a prolonged periode of time, either for pharmaceutical or for cosmetic applications. This paper shows that this result can be achieved by incorporating particles in emulsions specifically designed for this purpose.In order to evaluate the extent and duration of adhesion of such systems, an artificial substrate has been prepared and its surface energy and hydration degree have been adjusted to reproduce those of human skin. A hydrodynamic method has been used to study the removal either of crude particles or of H/L emulsion embedded particles after deposit on either artificial substrate or human skin. Immobilization of the particles on the skin for prolonged periods of times (up to 330 minutes) under immersion conditions, has been proved to be feasible. It has been shown to be dependent on formulation since particle retention was increased from 40% up to 98% when embedding the ...