Immobilization of heparin-mimetic biomacromolecules on Fe3O4 nanoparticles as magnetic anticoagulant via mussel-inspired coating.

Abstract

Here, we report the application of mussel-inspired surface coating to prepare heparin-mimetic biomacromolecules modified magnetic Fe3O4 nanoparticles as recyclable anticoagulant. Sodium alginate sulfate (SAS), which has the similar chemical structure and bioactivity with heparin, was synthesized at first. Dopamine (DA) was then grafted onto the backbone of SAS as the mussel-inspired adhesive macromolecule (DA-g-SAS), followed by being coated onto Fe3O4 nanoparticles. The SAS coated Fe3O4 nanoparticles could combine both the advantages of magnetic responsiveness and blood compatibility. The measurements revealed that the modified nanoparticles showed improved anticoagulant property as well as good recyclable property. The study provides a promising method to introduce nanomaterials into the field of hemodialysis. And the heparin-mimic polysaccharide biomacromolecules modified Fe3O4 nanoparticles can be considered as attractive material for potential application for hemodialysis.