Abstract
The cardiovascular graft associated complications limit the long-term patency of the graft and restrict the patient's life quality. In the present study, PLGA nanoparticles were covalently immobilized onto the woven form of crimped polyethylene terephthalate (PET, Dacron®) cardiovascular graft to treat the early thrombosis, inflammation, or bacterial infection via local delivery of therapeutic agents. PET surface was firstly functionalized to produce reactive amino groups used as anchor sites for covalent immobilization of PLGA nanoparticles by end-point technique. The functionalized surface characterized by electro kinetic analyzer showed marked negative surface potential values up to −41 mV at high pH value indicating the presence of amino groups on PET surface. The scanning electron microscopy observations of nano-coated PET showed topographic architecture of homogenously distributed monolayer of PLGA nanoparticles on the PET surfaces. Profoundly, the immobilized nanoparticles manifested stability under blood flow-mimetic conditions for 24 h. The cytotoxicity and biocompatibility of the nano-coated PET in mouse L929 fibroblasts revealed adequate biocompatibility in terms of the cellular adhesion and growth pattern without remarkable cytotoxicity.
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