Abstract
To compare ileal anastomoses in the immediate postoperative healing period after meloxicam use. Forty two male Wistar rats were randomly divided into two groups of 21, COX and control group. To COX meloxicam in combination with morphine was given in 3 days period. Control group received only morphine during the same period. Each group was divided into three sub-groups of 7, which were euthanized at 5, 10, and 21 days postoperatively. Comparison was based in histological evaluation of collagen type I and III using sirius red, immunohistochemical through vascular endothelial growth factor and matrix metalloproteinase-9. Healing process in scheduled periods did not show significant differences (p>0.05) between the COX and control groups during any of the periods. The use of meloxicam in the postoperative period following ileal anastomosis did not affect healing.
Highlights
The effects of non-steroid anti-inflammatory drugs on intestinal healing are still poorly understood and controversial
This study demonstrated that the use of meloxicam during the postoperative period after ileal anastomoses in Wistar rats did not significantly affect (p>0.05) the time of collagen fiber synthesis by activated fibroblasts
Immunohistochemical assessment of MMP-9 and vascular endothelial growth factor demonstrated that meloxicam did not have significantly impact (p>0.05) in angiogenesis and fibroblastic phase of the repair process
Summary
The effects of non-steroid anti-inflammatory drugs on intestinal healing are still poorly understood and controversial. Some authors have reported that non-steroid anti-inflammatory drugs promote intestinal healing, while others have shown their deleterious effects on intestinal healing by increasing the rate of anastomotic dehiscence which leads to a higher mortality rate[1,2,3,4]. The process of gastrointestinal healing, which is comprised by the stages of inflammation, deposition, and maturation of collagen, resembles the process in other wounds but is influenced by the peritoneum, which reacts to different trauma with peritonitis and/or formation of adhesions, as well as by the multiple layers of the gastric or intestinal wall[12,13]. The inflammatory phase is intense in the intestine and longer in the large intestine than in the small intestine[15]
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