Abstract
SummaryThe biological properties of the homocytotropic antibody (HCA) of the marsupial Setonix brachyurus (the quokka) were closely comparable to those of eutherian (placental species) IgE. However, the quokka HCA was indistinguishable from the IgG1 class. Agar gel electrophoresis, Sephadex G‐200 chromatography and sequential elution from DEAE‐cellulose and CM‐cellulose did not separate the passive cutaneous anaphylactic (PCA) and IgG1 passive haemagglutination (HA) activities in quokka antisera. No antigenic differences between the IgG1 HA antibody and the HCA were detected. In addition to quokka IgG1, tissue‐fixing IgG has been demonstrated in eutherian and avian species and thus it is suggested that the extant IgG and IgE classes evolved from a primitive cytotropic γ chain.
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