Abstract
AbstractElevated serum IgE levels gave rise to the hypothesis that type 1 immune reaction is implicated in the pathology of Bullous Pemphigoid. IgE serum levels were estimated in 91 patients with Bullous Pemphigoid (BP) and in 26 healthy individuals. In 30 of the patients, the dermal mast cell infiltrate and peripheral blood eosinophils (%) were studied. Patients were subdivided in four groups according in diagnostic criteria or treatment. It was found that all patients, including those receiving treatment, had considerably elevated serum IgE compared to controls. Patients fulfilling all criteria had markedly increased IgE compared to those with negative indirect immunofluorescence. A significant correlation was found between serum IgE and dermal mast cell infiltrate but not between serum IgE and peripheral blood eosinophils, or between peripheral eosinophilia and dermal mast cells. Immediate hypersensitivity parameters, systemic or local, are apparently involved in BP lesion formation although to date it remains unknown at which particular step such parameters might be crucial. The possible biological significance of IgE overproduction and its interrelationship with local inflammatory cellular events is discussed.
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