Immediate flare-up–like reaction of skin tests to betalactams with lymphangitis during drug provocation test

Abstract

Betalactam (BL) antibiotics are the most common cause of drug-induced hypersensitivity reactions (DHR). We present 2 clinical cases of patients with suspected immediate BL DHR who underwent drug allergy workup according to standardized diagnostic procedures, including skin tests (STs: prick, skin prick test, and intradermal tests [IDTs]) and drug provocation tests (DPTs).1 ST results became positive after the first DPT dose. The patients gave their consent to the diagnostic allergy workup and use of their deidentified data for research purposes.