Abstract
The immediate effects of methylphenidate on cognitive attention in 15 children (13 males, 2 females; mean age 9y 5m) with attention deficit hyperactivity disorder (ADHD) were assessed at Guy's Hospital, Great Ormond Street Children's Hospital, and Institute of Child Health, University College, London.
Highlights
This case report underscores the risks of adding folic acid to the drug regimen of patients with epilepsy treated with phenytoin
Folic acid appears to be a cofactor in the metabolism of phenytoin
Phenytoin pharmacokinetics before and after folic acid administration were reported from University of Iowa (Berg MJ et al Epilepsia 1992;33:712-720; see Ped Neur Briefs Sept 1992)
Summary
Phenytoin pharmacokinetics before and after folic acid administration were reported from University of Iowa (Berg MJ et al Epilepsia 1992;33:712-720; see Ped Neur Briefs Sept 1992). All subjects showed decreased serum folic acid following initiation of phenytoin treatment. The immediate effects of methylphenidate on cognitive attention in 15 children (13 males, 2 females; mean age 9y 5m) with attention deficit hyperactivity disorder (ADHD) were assessed at Guy's Hospital, Great Ormond Street Children's Hospital, and Institute of Child Health, University College, London.
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
