Abstract
In healthy human subjects, cimetidine reduces plasma clearance of indocyanine green (ICG) by approximately 25% (1). This reduction should reflect a similar decrease in liver blood flow (2) and it is suggested that this effect is mediated by the vascular H2-receptors. This finding has clinical implications in the management of patients with severe liver disorders. Omeprazole, a new suppressor of gastric acid secretion, is an inhibitor of the proton pump in the parietal cell. Omeprazole has no influence on the H2-receptors. As its effect on liver blood flow is unknown, it was decided to study the effect of omeprazole and cimetidine on apparent liver blood flow in healthy human subjects.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
