Abstract

This chapter presents a case study of a 50-year-old Iraqi man, who was presented with splenomegaly and pyrexia of unknown origin. A bone marrow aspirate was done as part of the investigations and unexpectedly showed Plasmodium falciparum parasites. The immature gametocytes that are seen include some that are sail-shaped, spindle-shaped or oval rather than the crescent-shaped macrogametocyte and sausage-shaped microgametocyte that are usually observed in the blood. This reflects the fact that gametocytes develop in the internal organs, including the bone marrow, rather than in the circulating blood. Some mature gametocytes were also present.

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