Abstract
We present a 71-year-old female patient who underwent 18F-PSMA-1007 PET/CT for suspected metastatic renal cell carcinoma (RCC), as RCC also shows high PSMA-expression in tumor neovascularization. 18F-PSMA-1007 PET/CT showed a high PSMA-avidity in the renal tumor, enlarged intra-abdominal and mediastinal lymph nodes. Moreover, PSMA-positive pleural, pulmonal and osseous lesions were found. However, histopathology revealed an immature plasma cell myeloma with an endothelial PSMA-expression of the neovasculature. This case illustrates the increased PSMA-avidity in multiple myeloma and highlights PSMA as a potential theragnostic target in multiple myeloma. For clinical routine, lymphatic diseases such as extramedullary myeloma should be considered as differential diagnosis in PSMA-avid renal masses on PET/CT.
Highlights
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A 71-year-old woman presented to the uro-oncological department with a newly diagnosed, left-sided renal tumor for further clinical workup and the subsequent initiation of therapy
Summary
TThhee pprree--kknnoowwnn eennllaarrggeedd llyymmpphh nnooddeess aallssoo sshhoowweeddaahhiigghhPPSSMMAA-a-avvididitiytyoonnPPEETT ((SSUUVVmmaaxx 1177..00)). Publisher’s Note: MDPI stays neutral with regard to jurisdictional claims in published maps and institutional affiliations. A 71-year-old woman presented to the uro-oncological department with a newly diagnosed, left-sided renal tumor for further clinical workup and the subsequent initiation of therapy. Contrast-enhanced computed tomography (CT), initially performed at the pelvis and the lower limbs to rule out arterial occlusion, revealed an incidental finding of an extensive, inhomogeneous, marginal contrast-enhancing renal tumor of the left kidney.
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