IMM0306, a fusion protein of CD20 mAb with the CD47 binding domain of SIRPα, exerts excellent cancer killing efficacy by activating both macrophages and NK cells via blockade of CD47-SIRPα interaction and FcɣR engagement by simultaneously binding to CD47 and CD20 of B cells

Jifeng Yu,Wei Zhang,Gui Zhao,Zhongxing Jiang,Dandan Liu,Dianze Chen,Liang Peng,Li Zhang,Song Li,Wenzhi Tian,Ruliang Zhang,Yongping Song,Xiaoping Tu,Huiqin Guo,Xing Bai,Sijin Liu,Chunmei Yang

doi:10.1038/s41375-022-01805-9

IMM0306, a fusion protein of CD20 mAb with the CD47 binding domain of SIRPα, exerts excellent cancer killing efficacy by activating both macrophages and NK cells via blockade of CD47-SIRPα interaction and FcɣR engagement by simultaneously binding to CD47 and CD20 of B cells

Jifeng Yu, Wei Zhang + Show 15 more

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https://doi.org/10.1038/s41375-022-01805-9

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Journal: Leukemia	Publication Date: Dec 27, 2022
Citations: 13	License type: open-access

Affiliation: First Affiliated Hospital of Zhengzhou University, Sino Biopharmaceutical (China)

#NK Cells #Excellent Efficacy + Show 7 more

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Abstract

IMM0306, a fusion protein of CD20 mAb with the CD47 binding domain of SIRPα, exerts excellent cancer killing efficacy by activating both macrophages and NK cells via blockade of CD47-SIRPα interaction and FcɣR engagement by simultaneously binding to CD47 and CD20 of B cells

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