Abstract
<p>Psoriasis is a skin disorder characterized by skin inflammation and plaques. Induction of psoriasis in animal model include following steps: a) Selection of animal model, b) Hair removing from the back or ear, c) treatment of skin with Aldara, a cream containing 5% imiquimod and d) Observation. Imiquimod-induced skin inflammation in animal model resembles with psoriasis.</p><p><strong>Video Clip:</strong></p><p><a href="https://youtube.com/v/QY-RESHbH-U">Psoriaisis-like skin:</a> 9 min 10 sec</p>
Highlights
We demonstrated the induction of imiquimod-induced psoriasis-like skin inflammation in mice
The scoring system should be developed based on the clinical Psoriasis Area and Severity Index (PASI)
Part 1: 9 min 10 sec Psoriasis is a chronic skin disease that causes skin cell to build up rapidly results in thick, scaly and itchy skin
Summary
The disease is characterized by skin inflammation, plaques and increased vascularity in dermis. The disease onset is generally between 15-25 years of age. It may affect people of all ages. Imiquimod-induced psoriasis-like skin inflammation in mice model is considered to have same resemblance with human psoriasis. The treatment of skin with Aldara (a cream containing 5% imiquimod) on the ears and hair-free back of mice results in skin inflammation (psoriasis-like lesions), redness and skin thickening within 5 days of application (van der Fits et al, 2009). Drugs like corticosteroids and cyclosporine A are found effective at treating psoriasis. In this visual experiment, we demonstrated the induction of imiquimod-induced psoriasis-like skin inflammation in mice
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