Abstract
To Editor.—The comments by Mofenson and co-workers must be considered seriously by any physician prescribing a potentially toxic medication. As popularity and availability of specific drugs increase, so will incidence of overdosage and abuse. Penny, in 19681reviewed reported instances of childhood imipramine poisoning and mentioned that the number would likely increase. There has even appeared a report of severe hypotension due to imipramine therapy wheretherepeutic dosageshave been employed.2 The incidence of toxic overdoses due to imipramine will decrease greatly if physician: Thoroughly educates parents to use and abuse of medication and importance of keeping all medications out of reach of children. Individualizes patients chosen to undergo imipramine therapy with careful follow-up of efficacy and indicated laboratory measurements. Employs use of strip packaging techniques from
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